in vivo Grade Oligonucleotides

Service Description

  • Manufacture and supply of oligonucleotides in large quantities (mg scale) suitable for animal administration
  • Standard QC, with optional sodium salt exchange and endotoxin testing
  • Available for the development of a wide range of oligonucleotide therapeutics, including ASOs, double-stranded RNAs, aptamers, etc.
  • Extensive range of modification options for oligonucleotide therapeutics
    Examples: Phosphorothioate (PS), 2′-MOE, 2′-F, 2′-OMe, 5-Methyl-dC, Locked Nucleic Acid
    Additional modifications are also available — see the full list here.

Key Features

Availability of various conjugates, including Tri-GalNAc, Cholesterol, Tocopherol, etc.
Seamless scale-up of oligonucleotides from in vitro to in vivo grade

Quotation & Order

Please submit your quotation request using our quotation request sheet or the inquiry form.
We will send your quotation within the same or next two business days.

  • * For modifications not listed in our standard offerings, or for custom synthesis using your own amidite, additional time may be required.
Quotation Request & Order Sheet
The quotation request sheet is available in Excel format for DNA, RNA, and modified oligonucleotide synthesis. It can also be used as an order form when placing your order.

Download a quotation request sheet

We recommend using Office 365.
If you are using an older version, please use this instead.
Inquiry Form
Quotation requests can easily be submitted online. This form can also be used to inquire about our products and services.

Go to inquiry form

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