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Pricing, Lead Time & Guaranteed Yield

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Product FeaturesProduct SpecificationsSynthesis Scale
Purification Grade
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Pricing (Modified Oligonucleotide)

You can calculate an estimated price using the formula below.
For a detailed quotation, please contact us.

Unit: JPY (tax excluded)
Estimated Price = 1. Price per Base / Modification + 2. Terminal Modification Price + 3. Purification Price
e.g. 0.05 µmol Scale, DNA 20 mer 5′ Phosphate Cartridge
↓ ↓ ↓
¥140 × 20 + ¥6,400 + ¥500 = ¥9,700

Click here for optional service pricing.

1. Price per Base / Modification

Unit: JPY (tax excluded)
Modification Name Price per Base / Modification Purification Remarks
0.05μmol
Scale		 0.2μmol
Scale		 1μmol
Scale		 Cartridge HPLC
Standard Bases
DNA 140 240 300 ✓ ✓
RNA 420 600 1,200 ✓ ✓
Mixed Bases 140 240 300 ✓ – Recommended:
Cartridge purification
Nucleic Acid Therapeutics – Screening and Animal Studies
Phosphorothioate (PS) 140 200 200 ✓ ✓ 11-50mer
2′-MOE [A,5-Me-C,G,T] 1,100 1,600 3,200 ✓ ✓
2′-F [A,C,G,U] 700 1,000 2,000 ✓ ✓
2′-OMe [A,C,G,U] 700 1,000 2,000 ✓ ✓
2′-OMe [T] 5,800 14,000 21,000 ✓ ✓
5-Methyl-dC 1,600 1,700 3,500 ✓ ✓
Locked Nucleic Acid 1,700 2,500 4,900 ✓ ✓
Acyclic Nucleic Acid (SNA) Please feel free to contact us. – ✓ 11-50mer
Acyclic Nucleic Acid (iL-aTNA)* Please feel free to contact us. – ✓ 11-50mer
Lipid and Ligand Conjugates – Drug Delivery System
dR-GalNAc [Beta] 94,000 94,000 123,000 – ✓
GalNAc〈C3〉 38,000 38,000 50,000 – ✓
Fluorescent Dyes and Quenchers – Imaging and qPCR / dPCR Probes
Fluorescein (6-FAM)-dT 28,000 28,000 37,000 ✓ ✓
TAMRA-dT 42,000 42,000 53,000 – ✓
Rhodamine (ROX)-dT 36,000 36,000 45,000 – ✓
Labeling – Detection and Purification
Biotin-dT〈standard〉 33,000 39,000 51,000 ✓ ✓
DIG-dT 23,000 38,000 51,000 – ✓
Reactive Functional Groups – Conjugation
Amino-dT〈C6〉 24,000 24,000 32,000 ✓ ✓
Azide-dT 31,000 31,000 43,000 – ✓
Alkynyl-dT 31,000 31,000 43,000 – ✓
Spacers
Spacer C3 6,800 9,000 13,000 ✓ ✓
Spacer 9 6,800 9,000 13,000 ✓ ✓
Spacer C12 7,500 11,000 17,000 ✓ ✓
Spacer 18 7,500 11,000 17,000 ✓ ✓
d-Spacer 12,000 12,000 18,000 ✓ ✓
r-Spacer 14,000 14,000 21,000 ✓ ✓
Modified DNA Bases
deoxyInosine (dI) 2,100 2,600 3,500 ✓ ✓
deoxyUridine (dU) 1,900 3,000 4,000 ✓ ✓
5-hydroxymethyl-dC 96,000 96,000 125,000 ✓ ✓ Flat rate per two bases
N6-Me-dA 21,000 21,000 31,000 ✓ ✓
8-oxo-dG 25,000 25,000 33,000 – ✓
8-oxo-dA 18,000 18,000 26,000 – ✓
5-Bromo-dU 8,000 8,000 12,000 ✓ ✓
8-Bromo-dA 13,000 13,000 20,000 ✓ ✓
pseudo-dU 26,000 26,000 34,000 ✓ ✓
8-Amino-dA 32,000 32,000 44,000 ✓ ✓
Reverse (Inverse) -Abasic 33,000 33,000 43,000 ✓ ✓
Modified RNA Bases
riboInosine (rI) 12,500 15,000 25,000 ✓ ✓
5-Methyl-rU (rT) 14,000 14,000 21,000 ✓ ✓
pseudo-rU 26,000 26,000 34,000 ✓ ✓
2,6-diaminopurine (DAP) 29,000 29,000 41,000 – ✓
Photo-Crosslinkers
CNV-K 15,000 15,000 25,000 ✓ ✓ 11-50mer
CNV-D 20,500 20,500 34,500 ✓ ✓ 11-50mer
  • This product is available only under a license agreement with Nagoya University. For inquiries, please contact us.

 

2. Terminal ModificationPrice

Unit: JPY (tax excluded)
Modification Name Price per Base / Modification Purification Remarks
0.05μmol
Scale		 0.2μmol
Scale		 1μmol
Scale		 Cartridge HPLC
Lipid and Ligand Conjugates – Drug Delivery System
3′Tri-GalNAc【NEW】 Please feel free to contact us. – ✓ 11-50mer
3′dR-GalNAc (Alpha) 13,000 13,000 24,000 – ✓ 11-50mer
3′GalNAc〈C3〉 8,000 8,000 15,000 – ✓ 11-50mer
5′Cholesterol〈TEG〉 17,000 17,000 26,000 – ✓
3′Cholesterol〈TEG〉 12,000 12,000 18,000 – ✓ 11-50mer
5′Tocopherol〈TEG〉 21,000 21,000 28,000 ✓ ✓
5′Phosphorylation – Ligation and 5′Modification of siRNA Guide Strands
5′Phosphate 6,400 6,400 11,000 ✓ ✓ Cartridge purification:
DNA only
5′Vinyl Phosphonate, 2′-OMe-U (5′VP)【NEW】 15,000 15,000 30,000 – ✓
Fluorescent Dyes and Quenchers – Imaging and qPCR / dPCR Probes
5′Fluorescein (6-FAM) 6,500 9,000 19,000 – ✓
3′Fluorescein (6-FAM) 8,000 11,000 22,000 ✓ ✓ 11-50mer
5′Cyanine3 18,000 20,000 30,000 – ✓
3′Cyanine3 18,000 20,000 26,000 – ✓ 11-50mer
5′TAMRA 7,500 10,000 29,000 – ✓
3′TAMRA 7,500 10,000 30,000 – ✓ 11-50mer
5′Rhodamine (ROX) 7,500 10,000 30,000 – ✓
3′Rhodamine (ROX) 8,000 11,000 29,000 – ✓ 11-50mer
5′Cyanine5 18,000 20,000 30,000 – ✓
3′Cyanine5 18,000 20,000 26,000 – ✓ 11-50mer
3′BHQ1 12,000 20,000 30,000 – ✓ 11-50mer
3′BHQ2 12,000 20,000 30,000 – ✓
3′BHQ3 18,000 51,000 77,000 – ✓
Dabcyl 18,000 18,000 24,000 – ✓ 11-50mer
Real-Time PCR Probe 22,500 27,500 ー – ✓ 11-30mer
ATTO-TEC Fluorescent Dyes – Imaging and qPCR / dPCR Probes
5′ATTO【NEW】 Please feel free to contact us. – ✓
3′ATTO【NEW】 Please feel free to contact us. – ✓
Labeling – Detection and Purification
5′Biotin〈standard〉 10,000 10,000 18,000 ✓ ✓
5′Biotin〈TEG〉 15,000 20,000 26,000 ✓ ✓
3′Biotin〈TEG〉 8,000 8,000 14,000 ✓ ✓ 11-50mer
5′DIG 19,000 19,000 28,000 – ✓
3′DIG 19,000 19,000 30,000 – ✓ 11-50mer
Reactive Functional Groups – Conjugation
5′Amino Modifier〈C6〉 5,000 5,000 9,000 ✓ ✓
3′Amino Modifier〈C6〉 5,000 5,000 11,000 ✓ ✓ 11-50mer
5′EC Amino Linker 5,000 5,000 9,000 ✓ ✓
5′Thiol〈C6〉 12,000 12,000 19,000 – ✓
3′Thiol〈C3〉 13,000 13,000 22,000 – ✓ 11-50mer
5′Azide 12,000 12,000 20,000 – ✓
3′Azide 13,000 13,000 23,000 – ✓ 11-50mer
5′Alkynyl 12,000 12,000 20,000 – ✓
3′Alkynyl 13,000 13,000 25,000 – ✓ 11-50mer
5′DBCO〈TEG〉 17,000 17,000 23,000 – ✓
Terminators – DNA Polymerase Extension Inhibition
3′Phosphate 6,500 9,000 16,000 ✓ ✓ 11-50mer
3′(2′,3′-ddC) 26,000 26,000 34,000 ✓ ✓ 11-50mer
3′idT 5,000 5,000 10,000 ✓ ✓ 11-50mer
Modified DNA Bases
3′Reverse (Inverse) -Abasic 19,000 19,000 35,000 ✓ ✓ 11-50mer
Antibiotics
3′puromycin 11,000 11,000 20,000 ✓ ✓ 11-50mer

 

3. Purification Price

Unit: JPY (tax excluded)
Purification Price per Sequence
0.05μmol
Scale		 0.2μmol
Scale		 1μmol
Scale
Cartridge 500 1,000 2,000
HPLC 5,000 6,000 12,000

 

Guaranteed Yield (Modified Oligonucleotide)

“Guaranteed yield” refers to the minimum amount delivered to the customer, representing the final yield obtained after all synthesis and purification have been completed.
The unit is expressed in “OD,” calculated from the absorbance at 260 nm measured using a spectrophotometer.
3′ end modifications are available for 11–50 mer sequences.

  • Cartridge purification is available for selected modified oligonucleotides only.
Purification Synthesis Scale Length Remarks
11-50mer 51-70mer 71-99mer
Cartridge 0.05µmol 0.5 OD ー ー 11–40mer
when including RNA
0.2µmol 1 OD 1 OD ー
1µmol 8 OD 4 OD ー
HPLC 0.05µmol 0.5 OD ー ー ー
0.2µmol 1 OD 1 OD 1 OD 11–70mer
when including RNA
1µmol 8 OD 4 OD 2 OD

 

Domestic Lead Time (Modified Oligonucleotide)

　　Orders are accepted until 16:00.
Orders placed after 16:00 will be processed as next-day orders. Thank you for your understanding.

We calculate the delivery schedule based on business days, counting the order date as Day 0.
Please note that the required lead time may be longer than usual depending on the number of oligonucleotides ordered or the sequence composition.

3′ end modifications are available for 11–50 mer.
For deoxyinosine (dI), deoxyuridine (dU), or mixed base insertions only, the lead time follows that of DNA synthesis at each scale (see details).

Applicable Targets   Domestic Lead Time*1
11-70mer 71-99mer
DNA 7-12 10-14
RNA   8-13*2 ー
  • Domestic lead time is based on business days.
  • Any sequence containing RNA follows the RNA lead time.
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