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in vivo grade
Na+ Salt Exchange
By replacing the counter cation from TEA+ to Na+, toxicity in in vivo experiments can be avoided.
| Item | Synthesis Scale | Price (JPY) |
| Na+ Salt Exchange* | 1 μmol | 12,000 |
| 0.5 mg | 14,000 | |
| 1 – 19 mg | 15,000 | |
| 20 – 199 mg | 40,000 | |
| 200 – 1000 mg | 60,000 |
- * For amounts over 1 g, the charge will be 60,000 JPY × number of grams.
Endotoxin Testing
To ensure that our products can be used without concern for in vivo toxicity, we confirm that the endotoxin level is below the guaranteed value.
| Item | Price (JPY) |
| Endotoxin Testing* | 30,000 |
- * Guaranteed level: ≤ 5 EU/mg. For modified oligonucleotide products, please contact us separately.
Delivery Form
You can add the following options for immediate use in experiments.
| Item | Price (JPY) |
| Annealing | Free |
| Supplied in solution | Free |
| Aliquoting* | Free (up to 10 aliquots) |
- *For 11 or more aliquots, please contact us.
Quality Control
You can choose from the following QC options based on your experiment.
Lead time may vary depending on the analysis.
| Item | Price (JPY) |
| Reverse-phase HPLC analysis | 20,000 |
| Ion-exchange HPLC analysis (up to 30 mer) | 25,000 |
DNA Synthesis Options
Your regular primers can be made RNase-free – ideal for RNA experiments such as reverse transcription (RT-PCR).
| Item | Price (JPY) | Domestic lead-time |
| RNase-free product (without QC) | 2,000 | + 2 – 5 business days |
| RNase-free product (with QC)* | 20,000 |
- * For products with QC, RNase activity is verified to be absent by measuring degradation profiles using a Bioanalyzer or TapeStation.
Mixed Bases
Suitable for degenerate PCR, SELEX (aptamer screening), and similar applications.
Custom ratio adjustment is available; pricing is per adjusted base mix.
| Item | Price (JPY) |
| Standard mix (DNA)* | Free |
| Custom ratio adjustment (DNA) | 2,000 |
| Custom ratio adjustment (RNA) | 5,000 |
| Custom mixed bases (DNA, RNA, Modified Base) | Please contact us |
- * Same as our standard “Mixed Bases (DNA)”. Mixing is free; base unit price is identical to DNA.
| e.g. | DNA custom base mixture 1 (dG:dC = 5:3) |
| DNA custom base mixture 2 (dA:dG:dC:dT = 2:1:3:1) | |
| RNA custom base mixture 3 (rG:rC:rU = 1:4:7) | |
| When synthesizing using the three adjusted mixtures above, the total charge will be: Oligo synthesis fee + (2,000 × 2 mixtures) + (5,000 × 1 mixture) |