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Cell-Based Assays & Screening

Service Description

Hokkaido System Science Co., Ltd. (HSS) has entered into a service agreement with ACEL, Inc. (ACEL) to provide customized cell testing and screening evaluation services for the research and development of oligonucleotide therapeutics.
ACEL has established a custom-made evaluation system based on reliability standards, providing comprehensive support from assay system construction and validation through to definitive, compliance-grade testing under those standards.

Service Details

① Cell-based Assays (by ACEL)

  • Evaluation of sample efficacy using cells tailored to your research purpose.
  • Over 1,000 assays conducted.
Examples of test

Melanocyte Epidermal keratinocyte Fibroblast
Melanocyte Epidermal keratinocyte Fibroblast
Melanin production suppression test Atopic dermatitis improvement test Collagen promotion test
Lung-cancer-derived cell Umbilical vein endothelial cell Brain-derived nerve cell
Lung-cancer-derived cell Umbilical vein endothelial cell Brain-derived nerve cell
Liver function Improvement test Angiogenesis test Nerve cell function promotion test
Key Features

Testing using iPS cells is available.*
Expert researchers provide comprehensive support throughout the testing process.

  • * ACEL holds a license from iPS Academia Japan, Inc.

Feeder-free iPS cell
Click here for details (ACEL website)

② Screening System Development (HSS / ACEL)

  • HSS will provide oligonucleotides for screening. (click here for details)
  • ACEL will develop screening systems tailored to research needs and provide end-to-end support, from cell imaging to quantitative analysis of image data.
Normal Human myotube cell (MHC staining)
Angiogenesis test
(left) Control (right) Addition of a promoting factor
Key Features

High-content screening (HCS) is available using PerkinElmer (now Revvity, Inc.) instruments, renowned for their leading global market share.

Operetta CLS

Operetta CLS
High-content screening (HCS)
  • Various quantitative data can be obtained from each cell.
  • Cellular features such as morphology and localization can be quantified.
  • Large numbers of samples can be processed at high speed.
  • Adherent cells and 3D structures can be directly analyzed.
  • A single integrated workflow allows measurement and analysis from start to finish.
  • A wide range of analysis applications is available.
  • Advanced analyses are possible.
Click here for details (ACEL website)

③ Sample Analysis (ACEL)

  • Flexible analysis of samples ranging from a few to over 1,000
  • Seamless service from cell-based assays to sample analysis

Gene and protein expression analysis

Gene and protein expression analysis

Cell analysis and sorting

Cell analysis and sorting

Cytokine and marker expression analysis

Cytokine and marker expression analysis

Metabolic analysis

Metabolic analysis

Evaluation Examples of Oligonucleotide Therapeutics in Cell-Based Assays
Drug efficacy and pharmacology tests
  • Evaluation of ASOs and siRNAs
  • Evaluation of exon skipping
  • Evaluation of decoy oligonucleotides
  • Evaluation of oligonucleotide adjuvants
  • Evaluation of RNA-editing oligonucleotides

Safety tests
  • Cytokine release assay

How to Request Our Services

STEP 1

Consultation
Please feel free to inquire about your required service by E-mail.
e.g. cell-based assays / screening system development / sample analysis
E-mail：dna@hssnet.co.jp

※ Free-of-charge web consultation is available on request.

STEP 2

Quotation
We will propose an appropriate test plan and quotation based on your inquiry.

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