Pricing, Lead Time & Guaranteed Yield

Pricing (Modified Oligonucleotide)
Guaranteed Yield (Modified Oligonucleotide)
Domestic Lead Time (Modified Oligonucleotide)

Ordering Inquiry

Modified Oligonucleotide Synthesis

Product Features
Synthesis Scale
Purification Grade
Pricing & Lead Time
Guaranteed Yield

Pricing (Modified Oligonucleotide)

You can calculate an estimated price using the formula below.
For a detailed quotation, please contact us.

Unit: JPY (tax excluded)
Estimated Price	=	1. Price per Base / Modification	+	2. Terminal Modification Price	+	3. Purification Price
e.g.		0.05 µmol Scale, DNA 20 mer		5′ Phosphate		Cartridge
		↓		↓		↓
		¥140 × 20	+	¥6,400	+	¥500	=	¥9,700

Click here for optional service pricing.

1. Price per Base / Modification

Unit: JPY (tax excluded)
Modification Name	Price per Base / Modification			Purification		Remarks
Modification Name	0.05μmol Scale	0.2μmol Scale	1μmol Scale	Cartridge	HPLC	Remarks
Standard Bases
DNA	140	240	300	✓	✓
RNA	420	600	1,200	✓	✓
Mixed Bases	140	240	300	✓	–	Recommended: Cartridge purification
Nucleic Acid Therapeutics – Screening and Animal Studies
Phosphorothioate (PS)	140	200	200	✓	✓	11-50mer
2′-MOE [A,5-Me-C,G,T]	1,100	1,600	3,200	✓	✓
2′-F [A,C,G,U]	700	1,000	2,000	✓	✓
2′-OMe [A,C,G,U]	700	1,000	2,000	✓	✓
2′-OMe [T]	5,800	14,000	21,000	✓	✓
5-Methyl-dC	1,600	1,700	3,500	✓	✓
Locked Nucleic Acid	1,700	2,500	4,900	✓	✓
Acyclic Nucleic Acid (SNA)	Please feel free to contact us.			–	✓	11-50mer
Acyclic Nucleic Acid (iL-aTNA)^*	Please feel free to contact us.			–	✓	11-50mer
Glycan and Lipid Ligands – Drug Delivery System
Galactose glycanNEW	–	Please feel free to contact us.		–	✓
GlycanX-dTNEW	–	Please feel free to contact us.		–	✓
dR-GalNAc [Beta]	94,000	94,000	123,000	–	✓
GalNAc〈C3〉	38,000	38,000	50,000	–	✓
Fluorescent Dyes and Quenchers – Imaging and qPCR / dPCR Probes
Fluorescein (6-FAM)-dT	28,000	28,000	37,000	✓	✓
TAMRA-dT	42,000	42,000	53,000	–	✓
Rhodamine (ROX)-dT	36,000	36,000	45,000	–	✓
Labeling – Detection and Purification
Biotin-dT〈standard〉	33,000	39,000	51,000	✓	✓
DIG-dT	23,000	38,000	51,000	–	✓
Reactive Functional Groups – Conjugation
Amino-dT〈C6〉	24,000	24,000	32,000	✓	✓
Azide-dT	31,000	31,000	43,000	–	✓
Alkynyl-dT	31,000	31,000	43,000	–	✓
Spacers
Spacer C3	6,800	9,000	13,000	✓	✓
Spacer 9	6,800	9,000	13,000	✓	✓
Spacer C12	7,500	11,000	17,000	✓	✓
Spacer 18	7,500	11,000	17,000	✓	✓
d-Spacer	12,000	12,000	18,000	✓	✓
r-Spacer	14,000	14,000	21,000	✓	✓
Modified DNA Bases
deoxyInosine (dI)	2,100	2,600	3,500	✓	✓
deoxyUridine (dU)	1,900	3,000	4,000	✓	✓
5-hydroxymethyl-dC	96,000	96,000	125,000	✓	✓	Flat rate per two bases
N6-Me-dA	21,000	21,000	31,000	✓	✓
8-oxo-dG	25,000	25,000	33,000	–	✓
8-oxo-dA	18,000	18,000	26,000	–	✓
5-Bromo-dU	8,000	8,000	12,000	✓	✓
8-Bromo-dA	13,000	13,000	20,000	✓	✓
pseudo-dU	26,000	26,000	34,000	✓	✓
8-Amino-dA	32,000	32,000	44,000	✓	✓
Reverse (Inverse) -Abasic	33,000	33,000	43,000	✓	✓
Modified RNA Bases
riboInosine (rI)	12,500	15,000	25,000	✓	✓
5-Methyl-rU (rT)	14,000	14,000	21,000	✓	✓
pseudo-rU	26,000	26,000	34,000	✓	✓
2,6-diaminopurine (DAP)	29,000	29,000	41,000	–	✓
Photo-Crosslinkers
CNV-K	15,000	15,000	25,000	✓	✓	11-50mer
CNV-D	20,500	20,500	34,500	✓	✓	11-50mer

This product is available only under a license agreement with Nagoya University. For inquiries, please contact us.

2. Terminal ModificationPrice

Unit: JPY (tax excluded)
Modification Name	Price per Base / Modification			Purification		Remarks
Modification Name	0.05μmol Scale	0.2μmol Scale	1μmol Scale	Cartridge	HPLC	Remarks
Glycan and Lipid Ligands – Drug Delivery System
5′Galactose glycanNEW	–	Please feel free to contact us.		–	✓
3′Galactose glycanNEW	–	Please feel free to contact us.		–	✓	11-50mer
5′GlycanXNEW	–	Please feel free to contact us.		–	✓
3′GlycanXNEW	–	Please feel free to contact us.		–	✓	11-50mer
3′Tri-GalNAc	Please feel free to contact us.			–	✓	11-50mer
3′dR-GalNAc (Alpha)	13,000	13,000	24,000	–	✓	11-50mer
3′GalNAc〈C3〉	8,000	8,000	15,000	–	✓	11-50mer
5′Cholesterol〈TEG〉	17,000	17,000	26,000	–	✓
3′Cholesterol〈TEG〉	12,000	12,000	18,000	–	✓	11-50mer
5′Tocopherol〈TEG〉	21,000	21,000	28,000	✓	✓
5′Phosphorylation – Ligation and 5′Modification of siRNA Guide Strands
5′Phosphate	6,400	6,400	11,000	✓	✓	Cartridge purification: DNA only
5′Vinyl Phosphonate, 2′-OMe-U (5′VP)NEW	15,000	15,000	30,000	–	✓
Fluorescent Dyes and Quenchers – Imaging and qPCR / dPCR Probes
5′Alexa Fluor™ 488/594/647/750*NEW	38,000	55,000	109,500	–	✓
3′Alexa Fluor™ 488/594/647/750*NEW	38,000	55,000	109,500	–	✓	11-50mer
5′ATTO	Please feel free to contact us.			–	✓
3′ATTO	Please feel free to contact us.			–	✓
5′Fluorescein (6-FAM)	6,500	9,000	19,000	–	✓
3′Fluorescein (6-FAM)	8,000	11,000	22,000	✓	✓	11-50mer
5′Cyanine3	18,000	20,000	30,000	–	✓
3′Cyanine3	18,000	20,000	26,000	–	✓	11-50mer
5′TAMRA	7,500	10,000	29,000	–	✓
3′TAMRA	7,500	10,000	30,000	–	✓	11-50mer
5′Rhodamine (ROX)	7,500	10,000	30,000	–	✓
3′Rhodamine (ROX)	8,000	11,000	29,000	–	✓	11-50mer
5′Cyanine5	18,000	20,000	30,000	–	✓
3′Cyanine5	18,000	20,000	26,000	–	✓	11-50mer
3′BHQ-1	12,000	20,000	30,000	–	✓	11-50mer
3′BHQ-2	12,000	20,000	30,000	–	✓
3′BHQ-3	18,000	51,000	77,000	–	✓
3′Dabcyl	18,000	18,000	24,000	–	✓	11-50mer
Real-Time PCR Probe	22,500	27,500	–	–	✓	11-30mer
Labeling – Detection and Purification
5′Biotin〈standard〉	10,000	10,000	18,000	✓	✓
5′Biotin〈TEG〉	15,000	20,000	26,000	✓	✓
3′Biotin〈TEG〉	8,000	8,000	14,000	✓	✓	11-50mer
5′DIG	19,000	19,000	28,000	–	✓
3′DIG	19,000	19,000	30,000	–	✓	11-50mer
Reactive Functional Groups – Conjugation
5′Amino Modifier〈C6〉	5,000	5,000	9,000	✓	✓
3′Amino Modifier〈C6〉	5,000	5,000	11,000	✓	✓	11-50mer
5′EC Amino Linker	5,000	5,000	9,000	✓	✓
5′Thiol〈C6〉	12,000	12,000	19,000	–	✓
3′Thiol〈C3〉	13,000	13,000	22,000	–	✓	11-50mer
5′Azide	12,000	12,000	20,000	–	✓
3′Azide	13,000	13,000	23,000	–	✓	11-50mer
5′Alkynyl	12,000	12,000	20,000	–	✓
3′Alkynyl	13,000	13,000	25,000	–	✓	11-50mer
5′DBCO〈TEG〉	17,000	17,000	23,000	–	✓
Terminators – DNA Polymerase Extension Inhibition
3′Phosphate	6,500	9,000	16,000	✓	✓	11-50mer
3′(2′,3′-ddC)	26,000	26,000	34,000	✓	✓	11-50mer
3′idT	5,000	5,000	10,000	✓	✓	11-50mer
Modified DNA Bases
3′Reverse (Inverse) -Abasic	19,000	19,000	35,000	✓	✓	11-50mer
Antibiotics
3′puromycin	11,000	11,000	20,000	✓	✓	11-50mer

Manufactured and sold under an intellectual property license from Life Technologies Corporation.

3. Purification Price

Unit: JPY (tax excluded)
Purification	Price per Sequence
Purification	0.05μmol Scale	0.2μmol Scale	1μmol Scale
Cartridge	500	1,000	2,000
HPLC	5,000	6,000	12,000

Guaranteed Yield (Modified Oligonucleotide)

“Guaranteed yield” refers to the minimum amount delivered to the customer, representing the final yield obtained after all synthesis and purification have been completed.
The unit is expressed in “OD,” calculated from the absorbance at 260 nm measured using a spectrophotometer.
As a general guideline, 1 OD corresponds to approximately 30 µg; however, the actual mass per OD varies depending on base composition and chemical modifications.

Purification	Synthesis Scale	Length			Remarks
Purification	Synthesis Scale	11-50mer	51-70mer	71-99mer	Remarks
Cartridge	0.05µmol	0.5 OD	–	–	11–40mer when including RNA
	0.2µmol	1 OD	1 OD	–
	1µmol	8 OD	4 OD	–
HPLC	0.05µmol	0.5 OD	–	–	–
	0.2µmol	1 OD	1 OD	1 OD	11–70mer when including RNA
	1µmol	8 OD	4 OD	2 OD	11–70mer when including RNA

3′ end modifications are available for 11–50 mer sequences.
Cartridge purification is available for selected modified oligonucleotides only.
Special guaranteed-yield conditions apply to Galactose Glycan and GlycanX. For details, please refer to the “Glycan Ligands” page.

Domestic Lead Time (Modified Oligonucleotide)

　　Orders are accepted until 16:00.
Orders placed after 16:00 will be processed as next-day orders. Thank you for your understanding.

We calculate the delivery schedule based on business days, counting the order date as Day 0.
For orders with 1µmol scale or more, the domestic lead-time will be one day longer than indicated below.
Please note that the required lead time may be longer than usual depending on the number of oligonucleotides ordered or the sequence composition.

Applicable Targets	Domestic Lead Time
Applicable Targets	11-70mer	71-99mer
DNA	7-12	10-14
RNA	8-13	–

Domestic lead-time for RNA will be applied for any oligos containing RNA base(s).
3′ end modifications are available for 11–50 mer sequences.
For oligos containing deoxyinosine (dI), deoxyuridine (dU), and/or mixed bases, with no other modifications, the domestic lead times for DNA synthesis apply. For details, please refer to the Domestic Lead Time (DNA) table.
Special lead-time conditions apply to Galactose Glycan and GlycanX. For details, please refer to the “Glycan Ligands” page.

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